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NIMUSTINE HYDROCHLORIDE |
| Synonyms. Nimustine hydrochloride; ACNU; Nimustina clorhidrato; Nidran; N'-((4-Amino-2-methyl-5- pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitrosourea hydrochloride; 1-(2-Cloroetil)-1-nitroso-3-((2-metil- 4-aminopirimidin-5-il)metil)urea clorhidrato; 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chloro ethyl) -3-nitrosourea hydrochloride; 1-(4-Amino-2-methylpyrimidine-5-yl)methyl-3- (2-chloro ethyl)- 3-nitrosourea hydrochloride; 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-1-(2-chloroethyl)-1- nitrosourea hydrochloride; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
42471-28-3 (net), 55661-38-6 (HCl) |
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EINECS RN |
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FORMULA |
C9H13ClN6O2·HCl |
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MOLE WEIGHT |
309.15 |
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H.S CODE |
2933.59.5900 |
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SMILES |
c1nc(C)nc(c1CNC(=O)N(N=O)CCCl)N.Cl |
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CLASSIFICATION |
Antineoplastic agent, Alkylating agent, Nitrosourea |
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EXTRA NOTES |
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
(MeSH) Other RN: 52208-23-8 |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to yellow crystalline powder |
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MELTING POINT |
185 ~ 187 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
Decomposes slowly in moisture |
| SOLVENT SOLUBILITY | Soluble in methanol. Slightly soluble in absolute ethanol, n-butanol. Practically insoluble in ethyl acetate, ether, chloroform, benzene, n-hexane. |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pH |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. Light-sensitive (Gradually turns to greenish in light) |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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Wikipedia Linking - Nimustine Google Scholar Search - Nimustine hydrochloride Drug Information Portal (U.S. National Library of Medicine) - Nimustine hydrochloride PubChem Compound Summary - Nimustine hydrochloride Drug Bank - Nimustine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Nimustine http://www.ebi.ac.uk/ - Nimustine http://www.ncbi.nlm.nih.gov/ - Nimustine |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to yellow crystalline powder |
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IDENTIFICATION |
positive (Test A,B) |
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CONTENT |
98.5% min |
| LOSS ON DRYING |
1.0% max |
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HEAVY METALS |
20ppm max |
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RELATED SUBSTANCES |
Total impurities:1.0% max, single impurity:0.5% max |
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MELTING POINT |
185 ~ 186 C |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
2811 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | III |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
Toxic if swallowed. May cause cancer. May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. |
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GHS |
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SIGNAL WORD |
Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H301 |
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P STATEMENTS |
P301 + P310 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
25 |
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SAFETY PHRASES |
36/37/39-45 |
T|
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| PACKING |
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Preserve in light-resistant and well-closed containers |